“The small sample and reagent consumption are key benefits of Gyrolab, which help contain costs. For PK and ADA studies, a method that is sensitive and consumes less volume is important.”
Johanna Mora, Bristol-Myers Squibb, Princeton, NJ, USA
Pharmacokinetics Studies
Pharmacokinetic characterization is often a key milestone of early clinical trials. It is essential to be able
to reach conclusions early-on and not lose precious time at this stage of development.
When working with small animal models in preclinical studies, often as little as 10–100 microliters of blood is available for analysis, which means that samples need to be used effectively. As Gyrolab requires extremely small sample volumes, it is possible to obtain full PK profiles for individual animals during small animal studies. Even in clinical studies, patient samples are typically required for many different analyses, so available sample volumes for PK analysis may be limited.
Gyrolab provides robust assays that facilitate easy comparison of assay results with no operator dependence.
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Pharmacokinetic (PK) studies in preclinical and clinical phases
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Development and implementation of ligand binding assays for quantification of free and total target protein and drug molecule respectively
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Get more out of your samples
Gyrolab performs assays at nanoliter scale, substantially reducing sample and reagent consumption. In small animal studies, especially with repeated sampling at short intervals, only 10-100 microliters of sample may be available for analysis. Gyrolab lets you obtain more information from each individual animal, allowing full PK profiles to be generated and consequently reducing the number of animals required for each experiment. Gyrolab also significantly reduces consumption of scarce or precious reagents.
Trust your results
High accuracy and precision ensure enhanced assay performance. Gyrolab provides excellent reproducibility and robustness so that you can be confident about scaling-up your projects. The flow-through format significantly reduces matrix effects and there are no problems with assay drift, either over time, or within a CD. High quality results mean less re-testing and increased workflow efficiency.
Develop and validate new assays within days
The flexible, open system and assay format provide the perfect platform for new assay development. Transfer of ELISA assays is extremely fast and simple. Through selection of CD-type, assay sensitivity can be adjusted to suit a wide range of analytical needs. Quick turn-around time can be achieved for assay development, validation and sample analysis.
