Quotient Bioresearch
Application of the Gyrolab in PK, Immunogenicity & PD analysis
Dr. Gaskell details how the flexibility of the Gyrolab platform allows for pharmacokinetic, immunogenicity and pharmacodynamic studies in different matrices
Parallel PK and immunogenicity analysis of a monoclonal antibody in Gyrolab
Dr. Jones reviews a recent project in which sponsor-developed assays for PK and immunogenicicity were transferred and validated in support of a pre-clinical study.
PK and PD analysis of proteins in different matrices using Gyrolab
Dr Roberts uses Cytokine IL-8 model analyte to compare various emerging analytical techniques and presents data comparisons for the different methods. He also presents data for four different analytes in serum using minimum required dilutions of between 1/2 and 1/20 in three different species.
Medimmune
Application of Gyrolab and other analytical techniques for the characterisation of ex vivo clinical PK samples
Development of a Clinical PK Assay using the Gyrolab Workstation
A detailed step-by-step approach on how to develop a PK assay on Gyrolab is presented by Dr. Goodman. Trouble-shooting assay set-up and evaluating reagents using Gyrolab Evaluator is also explained. Data for this phase I assay is compared with MSD platform and the pro's and con's of the systems are discussed.
Astra Zeneca
Pharmacokinetics in one mouse using the combination of multi-sampling and the Gyrolab platform
Dr. Davidsson describes how to derive one full PK profile from one mouse using the combination of multi-sampling and the Gyrolab platform.
PK analysis of antibodies and proteins using Gyrolab workstation
Dr Davidsson concludes that Gyrolab workstation is the most suitable bioanalytical platform for quantification of PK in mouse and other disease models because of its ability to handle small plasma volumes, the low reagent consumption and the large dynamic range while still offering a robust and sensitive immunoassay system
Merck Research Laboratories
Pharmacokinetic Immunoassays using Gyros Microfluidic Technology
Dr Roman uses three case studies of assay qualification to highlight the main advantages of using Gyrolab workstation for pharmacokinetic assays: reduction in sample volume, broader assay range, high throughput and the possibility to run assays overnight.
GlaxoSmithKline
The Gyrolab: A New Frontier in Immunoassay
Three cases studies of immunoassay transfer to the Gyrolab platform from ELISA formats are shown by Dr. Abberley. The result of the transfer include extended dynamic ranges and reduced sample comsumption.
Bristol-Myers Squibb
Application of the Gyrolab Workstation to Support Pharmacokinetic and Immunogenicity Assessments of Protein Therapeutics
Dr. Mora presents pharmacokinetic and immunogenicity studies of a protein therapeutic. Assay parameters are evaluated and compared to other assay platforms such as ELISA and MSD.
Pfizer
Transforming the Care of Animals for a Healthier World
Dr. James Messamore explains how a 100 fold reduction in reagent consumption and reduced hands-on and analysis time helps scientists at Pfizer Animal Health to faster go/no decision making and reduced cost.
Gyrolab at Pfizer UK
Dr Brady discusses current biologics and biomarker assay development and the impact that the Gyros platform has had. A comparison is made with existing assay formats. Advantages of outsourcing the assay format are explained and the vast improvement in data is demonstrated