The immunoassay principle underlies hundreds of applications used throughout the biotherapeutic workflow. Also referred to as ligand-binding or activity-binding assays, immunoassays provide critical data to support projects from discovery through to preclinical and clinical trials, bioprocess development and production.
The Gyros platform offers a multi-application solution, suitable for a broad spectrum of immunoassay formats. Working at nanoliter scale within an integrated, automated process transforms lab productivity, cuts project times and helps meet increased demands for testing.
Setting a standard from discovery to the clinic
The Gyros platform integrates and automates the steps in an immunoassay, cutting time to result, eliminating user error and freeing up analysts' time. Control through 21 CFR part 11 compliant software ensures that assays can be transferred through the biotherapeutic workflow.
Approximately one-third of biopharmaceutical companies and service providers have two or more Gyrolab workstations, often at different geographical sites.
Save time, labor, sample and reagents
Significant savings in the time and labor required for assay development are shown in this data from MedImmune.
Courtesy of MedImmune (Gyrolab Seminars 2008)
Gyrolab workstations provide the control and precision needed to run assays unattended, freeing up analysts' time for other tasks. Performing assays at nanoliter scale dramatically cuts consumption of samples and reagents.
Save time in development and QC
Work performed at MedImmune to develop a bioprocess-related impurity assay demonstrated the efficiency gains of the Gyros platform.
Reduced reagent consumption
Increased dynamic range
Increased success rate for 1st run
Cut testing times
* 2 analysts for 3 days, 1 analyst for 5 days
Saved labor
Data courtesy of MedImmune LLC, Gaithersburg, USA.
Gyrolab Viewer reveals the binding profile on each affinity column within a microstructure. This unique insight into individual data point enables comparison of binding profiles, facilitating reagent selection and the investigation of outliers
Gyrolab Viewer integrates and displays total fluorescence of 112 columns in
as little as 1.5 min.
Maximize lab productivity with an open, multi-application platform
The open design of the immunoassay platform ensures maximum productivity from every Gyrolab workstation. Applications such as biomarker monitoring, PK/TK analysis, product quantification and determination of HCP contaminants can be run wherever and whenever required.
Assays can be rapidly developed for multiple matrices, including human and animal sera or cell culture supernatant, with full flexibility in immunoassay format.
Make data-driven decisions based on high quality data, rapidly produced
Conventional techniques often require further sample dilution and run repeats, wasting time and sample. The Gyros platform reduces matrix effects and.measures samples over a broad dynamic range, from picogram to milligram, without the need to redevelop the assay.
High sensitivity, reduced sample consumption and faster assay.
Courtesy of Andrew Roberts, Quotient Bioresearch (Gyrolab Seminars 2009)
Gyros technology has revolutionized the way we operate.
Dr. K. Brady, Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Sandwich, UK.
A fantastic year ....12 new Tau and 4 new Abeta assays, 4 transferred Abeta assays, 2 new synaptic health biomarkers, 2 antibody screening assays, countless FTE hours saved.
R. Durham, Pfizer Inc., personal communication, December 2009