Pharmacokinetics of therapeutic antibodies

The results presented in the application report were generated in collaboration with a research group performing pharmacokinetic studies of therapeutic antibodies. An assay for quantifying a human monoclonal antibody drug molecule was transferred from ELISA format to Gyrolab Bioaffy.

Quantification in cynomolgus monkey serum

When comparing standard curves for the transferred assay when diluting the drug molecule in pooled cynomolgus monkey serum, undiluted and diluted 1:4 in Gyros standard diluent respectively, there was no evidence of matrix effects from the serum components.

Order application report 207: “Miniaturizing immunoassays for improved performance”.